The Best SAM-e Supplement You Can Buy | Smarter Reviews

The most effective SAM-e Supplements You Can Buy

Smarter Reviews' informative SAM-e supplements guide will help you make the right decision when it comes to buying the best one.

The most effective SAM-e Supplements You Can Buy

Although you may not be familiar with SAM-e (S-Adenosyl methionine), a naturally occurring compound found throughout your body, this molecule has a powerful effect on your health, particularly your brain function, mood and emotions, and even your joint strength.

In fact, when you are suffering from a SAM-e deficiency, you may experience a variety of problematic symptoms, such as depression, low energy levels, and joint pain.

For decades, SAM-e has been a popular dietary supplement in Europe, thanks to its numerous health benefits. (1) However, until recent years, it was a lesser-known supplement in the US.

Recently, though, SAM-e has surged in popularity in the U.S. And that's all thanks to the highly effective benefits of SAM-e supplements. Today, it’s time to learn more about this powerful supplement and what it can do for you.

As you begin to understand the powerful health benefits it offers, you may decide it is a supplement you would benefit from taking. Fortunately, there are plenty of supplements to choose from.

To help you narrow down the options, a review of five of the most popular SAM-e supplements can be found below. But first, here’s a quick look at everything you need to know about SAM-e. 

What is SAM-e?

As stated above, SAM-e is a naturally occurring compound that plays a key role in normal body function. (2) It is responsible for producing and regulating hormones, including those that cause emotional and physical distress, as well as maintaining your cell membranes.

In addition, it is involved in the production of cartilage which cushions and protects your joints. 

Multiple SAM-e studies have been conducted over the years with results consistently showing that SAM-e supplementation naturally treats depression and joint pain just as effectively as prescription antidepressants and NSAIDS. (3)

In fact, the National Institute of Mental Health asked researchers at Massachusetts General Hospital and Harvard Medical School to evaluate the effectiveness of SAM-e as an additive therapy to individuals struggling with major depression who were resistant to FDA-approved medications.

Patients who received the SAM-e supplement showed a 105% higher response rate and a 121% higher remission rate than those who did not. (4) Many people also reported a mild energy boost when taking the supplement

Who Could Benefit from SAM-e Supplements?

To be honest, just about anyone is likely to experience some benefits when taking a SAM-e supplement. For some people, though, SAM-e supplements can provide added or enhanced benefits.

  1. Mood Boost. Anyone who is struggling with depression (both chronic and acute), particularly when linked to stress, or simply wants to maintain their current mood could potentially benefit from SAM-e.
  2. Cognitive Enhancement. Anyone who is often tired, fatigued, or frequently experiencing brain fog.
  3. Mobility Support. Individuals who are suffering from osteoarthritis and joint pain may also benefit from it.
  4. Energy. Anyone diagnosed with chronic fatigue syndrome or fibromyalgia.

Keep in mind that you should always speak with your physician before starting any type of dietary supplement. This is especially true if you are taking prescription medications.

Warning signs & Reasons to Avoid Buying SAM-e 

If you are bipolar

If you are diagnosed with bipolar disorder, SAM-e has the potential to trigger a manic episode. (5)

If there are too many ingredients

The supplement you choose should include SAM-e and the ingredients necessary to form the tablet and keep it together. Other ingredients are likely just unnecessary fillers and additives.

If they are marketed in another language or via mass emails.

The FDA strongly suggests avoiding any supplement marketed almost completely through a language you don't understand or through a mass email. (6) They could be tainted and/or dangerous.

What You Should Look for in A good SAM-e Supplement

When selecting a SAM-e supplement, there are several things you should look for. This includes:  

An enteric-coated tablet

Your body more readily absorbs them and because of their special coating, they stay chemically stable longer, increasing their shelf life.

A reputable manufacturer

Dietary supplements are not highly regulated by the FDA, so you’ll need to be extra careful when selecting one. Look for one made by a well-known manufacturer that uses a pharmaceutical GMP-compliant facility, meaning it adheres to the same strict requirements as pharmaceutical drug companies.

A money-back guarantee

It’s important to note that SAM-e may not work for everyone. It’s a good idea to select a supplement that offers a satisfaction guarantee. This tells you the manufacturer stands behind their product and also ensures you don’t lose any money if you find it doesn’t work for you.

The qualities above are of the utmost importance when selecting your SAM-e supplement. That said, to find the best SAM-e supplements, it is a good idea to take into account these often-overlooked secrets.

The 2 Secrets of a High-Quality SAM-e Supplement

It does not contain talc

Talc is not considered food-grade by the Food and Drug Administration, and can actually be a carcinogen. Dubious supplements may use talc as a filler in their capsules, despite the official rebuke from the FDA.

It is soy-free

Soy may sometimes be present as soybean oil. Soy may be an allergen for some, replete with various negative health issues. It should be avoided when possible.

our specialized ranking system

Now, that you have a better understand of SAM-e and how you can benefit from the supplement, it’s time to look at some of the most popular supplements on the market. At Smarter Reviews, we employ a comprehensive evaluation system to analyze and measure the full value of products. This is based on ingredients, safety, potential effectiveness, return policies, and overall customer satisfaction. We call our method the Smarter Reviews Ranking System.

TOP 5 SAM-E Supplements

We looked at 5 of the most popular SAM-e supplements currently available. Here's what we found.

1. Nature Made SAM-E

Total Ranking

647 votes

9.6/10

A+

Overall Grade

  • Ingredient Safety
    8.4 Avg.

    9.7/10

  • Projected Effectiveness
    8.1 Avg.

    9.4/10

  • Value
    8.2 Avg.

    9.6/10

  • Return Policy
    8.8 Avg.

    9.3/10

  • Customer Satisfaction
    8.0 Avg.

    9.8/10

    Vote and Review

Vote and Review

5/10

PROS

  • Nature Made has a well-established reputation
  • All products are third-party verified
  • 100% money-back guarantee
  • Each capsule has an enteric coating

CONS

  • Many ingredients
  • Higher cost than some competitors
The Bottom Line

Each tablet includes 400 mg of SAM-e. Again, Nature Made has an established reputation for manufacturing supplements with a high potential for effectiveness. SAM-e is one of them. According to the label, effects should be felt in as little as 7-14 days. Customers are very satisfied with this product.

Comments frequently include statements such as “really worked for my depression and aching joints.” Based on this sort of feedback and the fact that it includes a 100% money-back guarantee if you are not completely satisfied, we have made the Nature Made SAM-e supplement our #1 pick.

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn About Our Top Pick 

2. Jarrow Formulas SAM-E

Total Ranking

647 votes

9.0/10

B+

Overall Grade

  • Ingredient Safety
    9.1 Avg.

    9.1/10

  • Projected Effectiveness
    9.0 Avg.

    9/10

  • Value
    8.9 Avg.

    8.8/10

  • Return Policy
    8.8 Avg.

    8.8/10

  • Customer Satisfaction
    9.1 Avg.

    8.9/10

    Vote and Review

Vote and Review

9/10

PROS

  • Well-known manufacturer
  • Side effects are rare

CONS

  • 200 mg tablets
  • Timeline of effectiveness not listed
  • Refunds not guaranteed
The Bottom Line

People have tried this supplement with overwhelmingly positive results. Reviewers often mention “my mood has been lifted,” “has helped me massively,” and “less anxious and overall better mood.” Customers who were not completely satisfied reported that the supplement left them feeling nauseous, as well as “feeling antsy.” At least a dozen reported that it has no effect on them whatsoever.

It is worth noting that, because the tablets are half the size of other brands, you may need to purchase more of this to equal their results.*

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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3. Puritan's Pride SAM-e

Total Ranking

328 votes

8.3/10

B+

Overall Grade

  • Ingredient Safety
    8.2 Avg.

    8.2/10

  • Projected Effectiveness
    8.1 Avg.

    8.5/10

  • Value
    8.2 Avg.

    8.2/10

  • Return Policy
    8.8 Avg.

    8.9/10

  • Customer Satisfaction
    8.0 Avg.

    8/10

    Vote and Review

Vote and Review

5/10

PROS

  • 400 mg doses also contain Vitamins C & B2
  • All products inspected and tested as many as 15 times to ensure purity, potency, and safety
  • Money-back satisfaction guarantee for 1 year from purchase date

CONS

  • Not many reviews
  • No timeline for effectiveness listed
The Bottom Line

Puritan’s Pride provides you with SAM-e as well as 48% of your daily vitamin B2 (riboflavin). While there are not many reviews yet, the ones currently available are quite positive. Unfortunately, there is no amount of time given for when you should begin to feel the effects.

Customers rave about this supplement, stating “Works great. I feel better. Have more energy.” One reviewer reports she has used it for more than 10 years. While not quite as good as the Nature Made product, this is still a notable, high-quality product.*

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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4. Nature's Trove SAMe

Total Ranking

581 votes

7.3/10

C

Overall Grade

  • Ingredient Safety
    8.4 Avg.

    7.7/10

  • Projected Effectiveness
    8.1 Avg.

    7/10

  • Value
    8.2 Avg.

    7.1/10

  • Return Policy
    8.8 Avg.

    8.2/10

  • Customer Satisfaction
    8.0 Avg.

    6.5/10

    Vote and Review

Vote and Review

5/10

PROS

  • Manufactured in a cGMP facility
  • GMO free and Kosher certified

CONS

  • Limited return policy
  • No timeline for effectiveness listed
  • A few poor reviews
The Bottom Line

Nature’s Trove company policy states they will only accept returns within 30 days of the purchase date. Also, returns are only allowed for regular-priced items in their original packaging and with a proof of purchase.

All supplements are lab tested, though the manufacturer does not state if this is done in a third-party lab. Reviews are mixed for this product. Some spoke its praises, with comments including “much better than other SAM-e pills I’ve tried” and “works great and a great price.” Others said it produced no discernible results.*

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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5. Doctor's Best SAM-E

Total Ranking

576 votes

7.1/10

C-

Overall Grade

  • Ingredient Safety
    8.4 Avg.

    7.1/10

  • Projected Effectiveness
    8.1 Avg.

    6.5/10

  • Value
    8.2 Avg.

    6.5/10

  • Return Policy
    8.8 Avg.

    8.3/10

  • Customer Satisfaction
    8.0 Avg.

    7.4/10

    Vote and Review

Vote and Review

5/10

PROS

  • Manufactured in cGMP-certified facility
  • Third-party tested for potency

CONS

  • Owned by overseas company
  • Manufactured outside U.S., which FDA warns against using
  • Does not disclose when effectiveness begins
  • No return guarantee
The Bottom Line

Doctor’s Best SAM-e has numerous positive comments, such as “It has been a life changer for me,” “recommended by my psychiatrist and I’ve been taking it for 4 years,” and “great natural solution for my depression and arthritis.” Also, a recent purchase of the brand by a Chinese corporation may have led to a drop in quality, though that is not verified.

When looking at the reviews of the few unsatisfied customers, it appears that they were simply not impressed with how it worked. Several stated they had also tried Nature Made, which did work.*

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More 

Citations

1. Clinical Considerations for SAM-e Use in Helping to Support a Healthy Mood http://www.pharmacytimes.com/publications/issue/2014/june2014/r636_june2014

2. SAM-e (S-adenosylmethionine, SAMe) https://www.webmd.com/diet/supplement-guide-sam-e#1

3. Studies Show Beating Depression Naturally with SAM-e is Superior to Antidepressant Drugs https://universityhealthnews.com/daily/depression/studies-show-beating-depression-naturally-with-sam-e-is-superior-to-antidepressant-drugs/

4. New Human Study Confirms Potent Antidepressant Effects of SAMe http://www.lifeextension.com/Magazine/2010/12/New-Human-Study-Confirms-Potent-Antidepressant-Effects-of-SAMe/Page-01

5. Investigating SAM-e for Depression http://www.psychiatrictimes.com/depression/investigating-sam-e-depression

6. Beware of Fraudulent Dietary Supplements https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm246744.htm

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