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How a Liver Supplement Can Help Reduce Bloating and Brain Fog
Learn how to spot a supplement that can deliver results and what makes a quality pre-fatty liver support product
Your liver does a lot of heavy lifting to keep you healthy and thriving. It aids in the metabolic process, helps with digestion, naturally detoxes your body, and is vital for proper blood circulation. For many people, the risk of pre-fatty liver has become a growing concern.
Many of us abuse our liver without even knowing it with things like drinking alcohol, eating processed foods, or fluctuating weight, which can lead to liver damage.
Typically, your liver does a good job filtering out all these toxins. But, with the number of toxins in today's food and environment, your liver may have a hard time keeping up and instead will store these occasional toxins in fat cells, potentially contributing to pre-fatty liver.
This can put unnecessary strain on your liver and can cause occasional fatigue, brain fog, and bloating, which are common symptoms of early liver damage.
ALT & AST Enzymes Hold the Key to Liver Health
What are ALT and AST Liver Enzymes?
AST and ALT are liver enzymes that help process nutrients and keep metabolism in check. When the liver is stressed, these enzymes can spill into the blood, signaling potential trouble.
Why Do These Enzymes Matter?
Balanced AST and ALT levels mean your liver is working smoothly. When they rise, it could signal stress, impacting digestion, detox, and energy. Keeping them in check will help strengthen your liver.
How Can I Support Healthy ALT & AST Levels?
A quality liver supplement should include ingredients like Milk Thistle and N-Acetyl Cysteine (NAC) to help support healthy AST and ALT levels. These nutrients aid detox, protect liver cells, and promote enzyme balance!
Key Benefits of a Quality Liver Supplement
Proper Liver Detoxification
Smooth Digestion
Long-Lasting Energy
Healthy Metabolism
Pre-Fatty Liver Support
Common Habits Negatively Affecting Your Liver
Alcohol Consumption
Eating Fried or Processed Foods
Fluctuating Metabolism
Cholesterol
The Problem with Liver Detox Drinks
Beware of "juice cleanses" that promise to heal your liver after a night out drinking.
Unfortunately, they often lack scientific backing and key ingredients necessary to support liver health—especially for those dealing with pre-fatty liver or early signs of liver stress.
What’s worse, juice cleanses have an unpleasant taste and odd texture, making it difficult to drink long-term.
Supplement capsules are flavorless, easy to take, and last longer than your ordinary detox drink.
How To Pick A Good Liver Supplement From The Junk
Today, millions of people’s livers are under strain, so it’s no wonder the market is flooded with supplements promising to reinforce the liver and detox it from everyday harmful chemicals and fat.
However, not all supplements are created equally. Many brands will cut corners, filling their supplements with cheap additives and using ineffective ingredients or weak dosages. That's why Smarter Reviews has compiled months of research about this emerging category. We’ll show you what to look for and what to avoid in a liver health supplement, and how it can help transform your whole-body health.
Before we dive into what makes a liver supplement effective and worth your hard-earned money, it’s important to understand what exactly a liver supplement can do for your health.
Feeling Blue? The Answer Might Rest In Your Liver
The mental fogginess and lack of concentration you are feeling may be attributed to a surprising organ in your body.
Did you know that the liver could be playing a role in your cognitive and mental health?
You see, the chemicals in your brain are affected by the performance of your liver. When a healthy liver is able to filter out everyday toxins from your body, it helps maintain your cognitive health. Even early signs of liver issues—like pre-fatty liver—can disrupt this process, contributing to issues like brain fog and low mental energy.
Recent studies are even showing that powerful antioxidants, like N-Acetyl Cysteine (NAC), can play a major role in supporting your mental health. NAC’s special properties protect your liver and may help reduce symptoms of stress, anxiety, and your overall cognitive health.
When Will You See Results?
A quality liver health formula begins supporting your body’s filter right away, and the more you take it the better you’ll feel.
Research shows that lasting results often occur after 90 days of consistent use. Here’s what you can expect:
Month 1: You may feel less discomfort as liver-nourishing nutrients start to tackle bloating and soothe your digestive system. This early support is especially helpful for those with pre-fatty liver signs or mild liver stress.
Month 2: As your overall liver works to repair itself. Don't be surprised if you notice more energy and a better mood.
Month 3: This is when peak support officially begins. In fact, some people report feeling a "night-and-day" difference with long-lasting digestive comfort, better weight management, and less brain fog. This is especially important for those managing pre-fatty liver or concerned about liver damage.
Smarter Reviews Tip: Consistency is key. So, make sure to stick with a quality formula for at least 3 months.
So with all these amazing health benefits in mind, which ingredients should you look for in a liver supplement and what should you avoid?
What Ingredients Make A Good Liver Supplement?
N-Acetyl Cysteine | 500-600mg Daily
NAC helps reduce oxidative stress in the liver to keep your immune system, cells, and tissues in check, helping support NAFL. It's also a basic building block of glutathione, which has been called "the mother of all antioxidants." Clinical studies show NAC may help protect liver cells from damage and support natural detoxification processes. Studies demonstrate NAC's effectiveness at 600mg daily for supporting healthy liver enzyme levels and antioxidant production.
Safety Considerations: Generally well-tolerated. Doses above 1,200mg daily may cause nausea or gastrointestinal upset. Those with bleeding disorders should consult a healthcare provider as NAC may affect blood clotting.
Tocotrienols | 100-200mg Daily
Tocotrienols are a very potent form of vitamin E, or as we like to call them, supercharged vitamin E. This powerhouse ingredient can work to help cleanse your liver of typical fat buildup and may help prevent non-alcoholic fatty liver disease. Research shows tocotrienols are significantly more effective than regular vitamin E at protecting liver cells. Studies show 200mg daily of mixed tocotrienols can help reduce liver fat accumulation and support healthy liver enzyme levels.
Safety Considerations: Very high doses (above 400mg daily) may increase bleeding risk, especially when combined with blood-thinning medications. Stick to recommended dosages for safety.
Milk Thistle (Silymarin) | 200-400mg Daily
Recent research has shown that milk thistle can help reduce irritation caused by everyday oxidative stress and toxins. It can also help support liver function, thus helping your metabolic process run more efficiently and help healthy weight management. The active compound silymarin has been studied extensively for liver protection. Most studies use 200-400mg of standardized silymarin extract daily, showing benefits for liver enzyme levels and cellular protection.
Safety Considerations: Generally safe for most people. Doses above 800mg daily may cause digestive upset, headaches, or allergic reactions in sensitive individuals. Those with ragweed allergies should use caution.
Zinc | 15-30mg Daily
Various studies have shown that zinc can help protect your liver from future stress, by reducing the lipid (or fat) buildup in your liver. Zinc is essential for proper liver enzyme function and helps support the liver's natural detoxification processes. Research shows 15-30mg daily helps maintain healthy liver function and supports enzyme activity.
Safety Considerations: Taking more than 40mg daily long-term can interfere with copper absorption and may cause nausea, vomiting, or immune system suppression. Always take with food to minimize stomach upset.
Selenium | 200-400mcg Daily
This powerful mineral is vital for helping your liver cleanse and detox itself. It's able to help your liver detox from unhealthy buildup by encouraging the production of an antioxidant called glutathione, which can help support healthy liver tissue cells and promote elasticity. Studies show 200-400mcg daily supports glutathione production and antioxidant activity in liver cells.
Safety Considerations: The upper safe limit is 400mcg daily. Excessive selenium (above 900mcg daily) can cause selenium toxicity, leading to hair loss, nail brittleness, fatigue, and gastrointestinal upset.
Beware: Cheap Fillers
Magnesium Stearate
This cheap filler is used to help bind ingredients together and lubricate the supplement so it doesn’t gum up when it is run through the manufacturing machines. Magnesium stearate adds no nutritional value and can become toxic to your system in large amounts.
Titanium Dioxide
Widely relied upon in supplement manufacturing as a coloring agent and binding mineral, titanium dioxide is banned in the European Union for use in food. Low-quality liver health supplements typically include this filler.
Top 5 Liver Health Supplements Of 2025
Below are the final rankings from our editors, complete with detailed reviews of each liver health supplement:
1. LiverMD®
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Total Ranking
9.7/10
A+
Overall Grade
PROS
- Over 1 Million Bottles Sold
- 5500+ positive reviews
- Formulated with 2 clinically studied ingredients: TocoGaia™ and Siliphos®
- Named Taste for Life’s Best Liver Support Supplement of 2021
- 500mg NAC
- Offers subscription plan
- Doctor formulated
- 90-day, risk-free, money-back, product guarantee
- Get 10% off with code 'First10'
CONS
- Frequently out of stock
The Bottom Line
We picked LiverMD® by 1MD Nutrition™ for our top spot because it’s the only supplement that meets our strict criteria.
LiverMD® contains two powerful, clinically studied ingredients: TocoGaia™, a clinical-strength tocotrienol, and Siliphos®, the highly bioavailable form of milk thistle’s active compound. It’s also enriched with 15mg zinc, 200mcg selenium, 500mg NAC, and other essential minerals that work synergistically to help your liver detox, repair, and stay healthy—especially important for those with early signs of liver stress or pre-fatty liver conditions.
LiverMD® has earned top industry recognition, including Taste for Life’s Best Liver Support Supplement of 2021 and the 2023 Delicious Living Supplement Awards – Gold, Consumer Choice for Favorite Detox & Cleanse.
Their return policy is also topnotch — a comprehensive, 90-day, risk-free, money-back guarantee, proving the company stands behind its products.
Our top pick has impressive survey results as well:
Over 80% of LiverMD® users saw significant improvements on liver test results**
- 92% experienced smoother digestion***
- 91% felt improved mental clarity****
**Based on a survey of 108 1MD Nutrition™ customers***Based on a survey of 216 1MD Nutrition™ customers
****Based on a survey of 195 1MD Nutrition™ customers
*Results are based on users' personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see product website for more information.
Get 10% off2. Dose for Your Liver
Total Ranking
8.9/10
B+
Overall Grade
PROS
- Contains quality ingredients
- Contains milk thistle
CONS
- Higher cost per serving
- Limited refund policy only for unopened products
- Missing 3 key ingredients
The Bottom Line
Landing at #2, Dose for your liver includes a group of quality ingredients, including milk thistle. The company ran a clinical study on its liver health formula which showed good results—although it only had 30 participants.
Unfortunately, Dose for your liver is missing key ingredients like tocotrienol, selenium, and zinc.
Consumers should also know that Dose’s return policy is not ideal. First, they don’t say how long their guarantee is. Second, they have to approve your return by email. And worst of all, you can only get a refund for an unopened product.
*Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
3.LiverWell
Owned by the Smarter Reviews Group of Companies
Total Ranking
9.7/10
A+
Overall Grade
PROS
- 400 mg of L-cysteine
- Milk thistle
- Selenium
- Zinc
- GMP compliant
- 365-day money-back guarantee
CONS
- Sold only in the US
- A higher dosage of 800mg NAC may not be suitable for those with specific health concerns
The Bottom Line
Its name might say "liver," but this formula provides excellent immune and respiratory support as well.
LiverWell is made with 400mg of L-cysteine, as well as milk thistle, 15mg zinc, 200mg selenium, 800mg NAC, and 100mg alpha lipoic acid. Like L-cysteine, these ingredients are known to aid in detoxification and help fortify the immune system.
This product is manufactured in GMP-compliant facilities to ensure safety and purity in every bottle.
To top things off, Live Conscious backs all of their products with a comprehensive, 365-day return policy, zero questions asked.
*Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More4. Liver Cleanse
Total Ranking
8.7/10
B+
Overall Grade
PROS
- Contains milk thistle
- Clean ingredients
CONS
- Mixed customer reviews
- Missing key ingredients
- Nutrient label shows total proprietary blend dosage, but lacks individual ingredient dosages, making it harder to determine efficacy of specific ingredients
The Bottom Line
Coming in at number 4 on our list is Liver Cleanse by Gaia Herbs. This product supports healthy liver function, involving both detoxification and elimination.
However, this formula is still missing some key ingredients, such as zinc and selenium, and other important minerals that help detox and repair your liver in the long term.
*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More5. Liver Support
Total Ranking
7.9/10
C+
Overall Grade
PROS
- Contains a potent form of milk thistle
CONS
- Lacks key ingredients like zinc and tocotrienols
- No money-back guarantee
- Mixed customer reviews
The Bottom Line
Rounding off our list is Liver Support by Vital Nutrients. It’s formulated with lots of important nutrients and ingredients, such as Silybin, a potent form of milk thistle. But once again, it lacks some key components, such as zinc and tocotrienols, for it to be a truly top-notch liver support supplement.
It’s worth pointing out that some customers said they did not experience any of the desired results and were disappointed with the product.
Potential customers should also take into consideration that there is no money-back guarantee for Vital Nutrients products.
*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn MoreDisclaimer:
Smarter Reviews is owned and operated by the same company that owns certain products featured on this website, including the products ranked number one.
In addition, we receive compensation from certain companies whose products are featured on this website when you purchase a product using the links on this website.
Go back to pageOur Main Sources
Sources used for research purposes. Smarter-Reviews.com are not officially affiliated with these sites.
What You Will Learn:
Estimated Read Time 5 Minutes
Benefits of a Quality Liver Supplement
CITATIONS
- https://www.ncbi.nlm.nih.gov/books/NBK279393/
- http://www.tocotrienolresearch.org/liver-health/
- https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/
- https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/