Advertising Sponsored by 1MD Nutrition, the Makers of GlucoseMD 

2025’s Top 5 GLP-1 Supplements

Do trendy GLP-1 supplements actually work for weight management? Here’s what to look for + what to avoid

Advertiser Disclosure

infographic

The weight management industry's best-kept secret isn't another new diet or expensive treatment - it's a hormone that's already inside your body, quietly controlling how you process food and regulating blood sugar. 

It’s called GLP-1 and it's more than just a trending topic. It's a biological breakthrough in weight management

And researchers have uncovered something remarkable: Certain natural compounds can aid in your body's own GLP-1 production. At the forefront of this discovery is berberine, a powerful plant that's been shown to enhance GLP-1 levels, appetite regulation, and support healthy metabolism.

It's no wonder that GLP-1 supplements featuring berberine have emerged as a natural, cost-effective solution for those seeking to transform glucose and weight management journey. However, not all formulas are created equal. Many brands cut corners, filling their supplements with cheap additives and using ineffective ingredients or weak dosages.

That's why Smarter Reviews has compiled months of research about this emerging category. We'll show you what to look for and what to avoid in a quality GLP-1 supplement, and how it can help transform your whole body health.

Key Benefits of a Quality GLP-1 Supplement

🍎 Promotes Appetite Suppression

By increasing satiety signals in the brain, GLP-1 helps reduce hunger, making it easier to manage cravings and control portion sizes, assisting in effective weight management.

🩸 Enhances Blood Sugar Control

GLP-1 supplements promote efficient insulin secretion and slow down gastric emptying, helping maintain stable blood glucose levels and reducing the risk of spikes and crashes.

⚖️ Improves Weight Management

GLP-1 aids in controlling portion sizes and caloric intake, making it an effective tool for managing weight.

📈 Helps Break Bad Habits

GLP-1 influences the brain's reward system, which can help reduce cravings

Here’s How GLP-1 Works

After a meal, GLP-1 is released to stimulate insulin production in the pancreas. This process moves sugar from the blood and into cells.

GLP-1 helps regulate the digestion of food in the stomach, helping control appetite and reduce food intake. To top it off, the hormone affects hunger signals from the brain to improve overall calorie consumption.

Why is Berberine Important?

Berberine helps increase GLP-1 production in the pancreas and intestines, naturally supporting appetite control. Studies show that beyond its GLP-1-boosting properties, berberine also supports healthy blood sugar balance - making it a particularly valuable compound for weight management.

Top 3 Ingredients for GLP-1 Production

Berberine

This bioactive compound is sourced from the Berberis shrub and has been used for centuries. Today, berberine enhances GLP-1 activity, appetite regulation, and improves insulin sensitivity.

Cinnamon Bark Extract

Cinnamon bark contains unique compounds that enhance insulin function, keeping blood sugar levels balanced. Clinically studied extracts maximize glucose support, enabling better metabolic efficiency.

Chromium

Chromium is an essential trace mineral that’s primarily known for its role in enhancing insulin action and improving glucose metabolism. It helps the body process carbohydrates, fats, and proteins more efficiently, contributing to stable blood sugar levels.

Navigating the supplement market can be daunting, with many brands cutting corners using cheap fillers and ineffective ingredients. Here’s what to avoid:

What to Avoid in a GLP-1 Supplement

Zero scientific research or Expert Backing

Weak Dosages

No Money-back Guarantee

Top 5 Blood Glucose Supplements Of 2025

We've compiled a list of what we've found to be the top five products in this category on the market today.

1. GlucoseMD

Owned by the Smarter Reviews Group of Companies

hat
a bottle of medicine

Total Ranking

9.7/10

A+

Overall Grade

PROS

  • Cardiologist-recommended
  • Supports GLP-1 production
  • Contains potent dose of berberine
  • Patented & clinically-studied ingredients
  • Third-party tested
  • Non-GMO: Price point
  • 90-day money-back guarantee

CONS

  • Frequently out of stock
The Bottom Line

We picked GlucoseMD by 1MD NutritionTM for our top spot because it’s the only supplement that meets our strict criteria.

GlucoseMD not only uses a steady dose of berberine, it contains clinically studied cinnamon bark extract for GLP-1 support. The experts at 1MD NutritionTM also made sure to formulate their supplement with powerful dosages to help promote healthy weight management. 

This was one of the only products that we could verify had no hidden additives or artificial ingredients

GlucoseMD's long-term benefits include lasting improvements to weight management and insulin support.

Additionally, their return policy is top notch — a comprehensive, 90-day, risk-free, money-back guarantee, proving the company stands behind its products.  All in all, GlucoseMD by 1MD NutritionTM is our top pick.

Learn More

2. GLP-1 Daily

hat

a bottle of red liquid

Total Ranking

9.5/10

A

Overall Grade

PROS

  • OBGYN backed
  • 90-day money-back guarantee

CONS

  • Price point  
  • Lacks berberine
  • Money-back guarantee for first order only
The Bottom Line

Coming in at number 2 on our list is GLP-1 Daily by Lemme, owned by Kourtney Kardashian.

It earned #2 on the list for its patented ingredients, OBGYN endorsement, and research. 

Unfortunately, celebrity-owned GLP-1 Daily lacks berberine, a crucial ingredient for a quality GLP-1 supplement. In addition, its delivery method is in the form of a gummy, possibly affecting effectiveness. 

At $80 for one bottle, its the most expensive GLP-1 supplement on the list.  Additionally, Lemme offers a poor return policy with returns only accepted for your first bottle. 

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More


Empty heading

3. GLP-1 Boost

graphical user interface, application
a white bottle of shampoo

Total Ranking

8.9/10

B+

Overall Grade

PROS

  • Contains berberine
  • Supports weight management
  • Positive reviews
  • Expedited shipping

CONS

  • Lacks proper cinnamon bark extract and chromium
  • Not expert-backed
  • No clinical studies
  • Unclear return policy
The Bottom Line

#3 on the list is GLP-1 Boost by Ivy RX. 


It includes a steady dose of berberine and claims to support healthy weight management and blood glucose levels.

But we were disappointed to see that the ingredients label is not displayed on the product page, making potential fillers possibly undisclosed.  

Other downsides of this product is its high price point and unclear return policy. However, with berberine in its formula, GLP-1 boost may be worth a try.

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

4. Metabolism Ignite

hat
bottle

Total Ranking

8.2/10

B-

Overall Grade

PROS

  • Clinical studies 
  • Doctor-recommended
  • GMP-certified

CONS

  • Contains fillers
  • Lacks berberine & cinnamon bark extract 
  • Money-back guarantee only after 90 days
The Bottom Line

Number four on our list is Metabolism Ignite.

While it doesn’t have all of our favorite ingredients, it’s hard to argue with its clinical studies! In a clinical study, Metabolism Ignite, can help reduce cravings by up to 10%. We appreciate that Veracity was willing to put their whole product to the test, rather than just individual ingredients.

Veracity's formula supports balanced blood glucose levels, GLP-1 support, & boosts heart health. 

It claims to be backed by MDs, but we had difficulty providing proof. Unfortunately, Veracity will only accept returns after trying the product for 90 days.  So, if you only see lackluster results, you can get your money back after 3 months.

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

5. GLPLUS+

number
a white bottle of cleaning liquid

Total Ranking

7.9/10

C+

Overall Grade

PROS

  • Low price point
  • Contains berberine and cinnamon extract
  • GMP-certified

CONS

  • Unclear return policy
  • Unclear expert-backing 
The Bottom Line

Finally, coming in at number five on the list is GLPLUS+. This formulation packs a lot of ingredients… but that doesn’t make it a great supplement. In fact, it packs so much in that it completely overlooks adding potent dosages or clinically studied ingredients. In other words, it’s trying to do too much and as a result isn’t doing much at all. 

It’s also worth pointing out that while many customers left favorable reviews, there were some who complained about an upset stomach and headache after taking this product. 

However, GLPLUS+ is priced reasonably for those who are very budget conscious.

*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More