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2024's Top NAC Supplements for Liver Repair
Discover what makes N-acetyl cysteine your next “antioxidant hero” & what to look for in a quality NAC liver supplement
Did you know that the effects of NAC are tied to Nobel Prize-winning research in liver health?
N-acetyl cysteine is widely known for boosting the production of glutathione, a powerful antioxidant that aids in cell repair, protein synthesis, and detoxification.
And this isn’t a recent discovery — NAC has been recommended by experts since the 1960s for that exact reason. as we age, our body’s glutathione levels begin to decline, and factors like poor nutrition, pollutants, and alcohol can expedite the process.
This can strain your liver, causing it to struggle to filter the toxins entering your body, and can leave you feeling fatigued, bloated, and foggy.
But when you incorporate NAC supplements into your daily routine, the results can be extraordinary…
Key Benefits of a Quality Liver Supplement
Aids in Glutathione Production
This boosts the body's natural antioxidant defenses to help combat oxidative stress.
Supports Liver Repair
When your liver is strained, it struggles to filter out harmful toxins such as alcohol, fatty foods, & environmental pollutants. NAC plays a major role in the detoxification process and maintaining your liver strength.
Improves Energy Levels
It helps your body produce energy more efficiently and reduce long-term fatigue.
Promotes Restful Sleep
Balanced glutathione levels can calm brain activity and reduce inflammation, helping make it easier to fall asleep and stay asleep.
Strengthens Immunity
NAC’s anti-inflammatory properties help combat “unwanted guests” in the body and keep you feeling your best.
Common Habits Negatively Affecting Your Liver
Alcohol Consumption
Eating Fried or Processed Foods
Fluctuating Metabolism
Pollutants
However, not all supplements are created equally. Many brands cut corners, filling their supplements with cheap additives and using ineffective ingredients or weak dosages.
That's why Smarter Reviews has compiled months of research about this emerging category. We’ll show you what to look for and what to avoid in a NAC supplement, and how it can help transform your whole body health. For optimal results, look for a formula that contains around 600 mg of NAC.
Feeling Blue? The Answer Might Rest In Your Liver
The mental fogginess and lack of concentration you are feeling may be attributed to a surprising organ in your body.
Did you know that the liver could be playing a role in your cognitive and mental health?
You see, the chemicals in your brain are affected by the performance of your liver. When a healthy liver is able to filter out everyday toxins from your body, it helps maintain your cognitive health.
Recent studies are even showing that powerful antioxidants, like N-Acetyl Cysteine (NAC), can play a major role in supporting your mental health. NAC’s special properties protect your liver and may help reduce symptoms of stress, anxiety, and your overall cognitive health.
So with all these amazing health benefits in mind, which ingredients should you look for in a liver supplement and what should you avoid?
What Ingredients Make A Good Liver Supplement?
N-Acetyl Cysteine
NAC helps reduce oxidative stress in the liver to keep your immune system, cells, and tissues in check. It’s also a basic building block of glutathione, which has been called “the mother of all antioxidants.” You can find it in a variety of meats, seafood, and turkey.
Tocotrienols
Tocotrienols are a very potent form of vitamin E, or as we like to call them, supercharged vitamin E. This powerhouse ingredient can work to help cleanse your liver of typical fat buildup.
Milk Thistle
Recent research has shown that milk thistle can help reduce irritation caused by everyday oxidative stress and toxins. It can also help support liver function, thus helping your metabolic process run more efficiently and help healthy weight management.
Zinc
Various studies have shown that zinc can help protect your liver from future stress, by reducing the lipid (or fat) buildup in your liver.
Selenium
This powerful mineral is vital for helping your liver cleanse and detox itself. It’s able to help your liver detox from unhealthy buildup by encouraging the production of an antioxidant called glutathione, which can help support healthy liver tissue cells and promote elasticity.
When Will You See Results?
A quality liver health formula begins supporting your body’s filter right away, and the more you take it the better you’ll feel.
Research shows that lasting results often occur after 90 days of consistent use. Here’s what you can expect:
Month 1: You may feel less discomfort as liver-nourishing nutrients start to tackle bloating and soothe your digestive system.
Month 2: As your overall liver health starts to improve, don’t be surprised if you notice more energy and a better mood.
Month 3: This is when peak support officially begins. In fact, some people report feeling a "night-and-day" difference with long-lasting digestive comfort, better weight management, and less brain fog.
Smarter Reviews Tip: Consistency is key. So, make sure to stick with a quality formula for at least 3 months.
Top 5 NAC Supplements Of 2024
Below are the final rankings from our editors, complete with detailed reviews of each NAC supplement:
1. LiverMD®
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Total Ranking
9.7/10
A+
Overall Grade
PROS
- Gastroenterologist-formulated
- Named Taste for Life’s Best Liver Support Supplement of 2021
- 500 mg NAC
- Formulated with 2 clinically studied ingredients: TocoGaia™ and Siliphos®
- GMP-certified
- Third-party tested
- NON-GMO
- 90-day money-back guarantee & free returns
- Get 10% off with code 'First10'
CONS
- Frequently out of stock
The Bottom Line
Gastroenterologist-formulated LiverMD® by 1MD Nutrition™ has been awarded our top pick for its comprehensive ingredients and potency.
LiverMD® contains a whopping 500 mg of NAC for powerful glutathione production. Plus, it includes two clinically studied, patented ingredients: TocoGaia™, a clinical strength tocotrienol, and Siliphos®, the bioavailable active ingredient in milk thistle. LiverMD® is also formulated with ALA, zinc, selenium for the ultimate liver detox.
To top it off, LiverMD® was recently named 2023 Delicious Living Supplement Awards - Gold, Consumer Choice for Favorite Detox & Cleanse.
And with their 90-day money-back guarantee and free returns, this makes it an obvious first choice.
Our top pick has impressive survey results as well:
Over 80% of LiverMD® users saw significant improvements on liver test results**
- 92% experienced smoother digestion***
- 91% felt improved mental clarity****
**Based on a survey of 108 1MD Nutrition™ customers***Based on a survey of 216 1MD Nutrition™ customers
****Based on a survey of 195 1MD Nutrition™ customers
*Results are based on users' personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see product website for more information.
Get 10% off2.LiverWell
Owned by the Smarter Reviews Group of Companies
Total Ranking
9.7/10
A+
Overall Grade
PROS
- 800 mg NAC
- 80 mg Siliphos® milk thistle
- ALA, Selenium, Zinc
- GMP compliant
- 365-day money-back guarantee
CONS
- Sold only in the US
The Bottom Line
Its name might say "liver," but this formula also has excellent immune and respiratory support as well.
LiverWell is made with 800 mg of NAC, as well as patented milk thistle, zinc, selenium, and alpha lipoic acid. Like NAC, these ingredients are known to aid in detoxification and help fortify the immune system.
This product is manufactured in GMP-compliant facilities to ensure safety and purity in every bottle.
To top things off, Live Conscious backs all of their products with a comprehensive, 365-day return policy, zero questions asked
*Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More3. NAC
Owned by the Smarter Reviews Group of Companies
Total Ranking
9.7/10
A+
Overall Grade
PROS
- 500 mg NAC
- Gluten-free
- Manufactured in the USA
CONS
- Contains fillers
- Unclear return policy
- Not expert-backed
The Bottom Line
NAC by Thorne Nutrition is another just-NAC supplement. It contains 500 mg of NAC, making it a great option for first-time users. It’s also worth noting that Thorne Nutrition is UFC’s official supplement partner.
However, Thorne’s NAC formula contains fillers, which can potentially lead to unpleasant side effects.
Customers should also take into consideration that the return policy is unclear and no money-back guarantee is mentioned.
*Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More4. Anti Alcohol
Total Ranking
8.7/10
B+
Overall Grade
PROS
- 1200 mg NAC
- Milk thistle extract
- Vitamin E, selenium, & zinc
- Manufactured in the USA
- NON-GMO
- 365-day money-back guarantee
CONS
- ALA
- Contains fillers
- Return shipping cost
The Bottom Line
Don't let the name fool you: Life Extension's Anti-Alcohol is a powerhouse immune-health supplement.
Made with 1200 mg of NAC per serving, this robust formula also contains selenium, zinc, and vitamin E for comprehensive immune support.
While there's a lot to like about this product, it’s important to be aware that it lacks ALA, clinically-studied milk thistle & vitamin E, and uses fillers in its formula.
Life Extension offers a 100% satisfaction, money-back guarantee — but with a few conditions. You will need to provide your reason for returning the product and pay return shipping.
However, for the price point and steady dose of NAC, it earned the spot of #4 in our top 5.
*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More5. NAC
Total Ranking
8.7/10
B+
Overall Grade
PROS
- 1000 mg NAC
- Manufactured in the USA
- NON-GMO
- 60-day money-back guarantee
- Third-party tested
CONS
- Contains fillers
- Return shipping cost
The Bottom Line
As its name implies, NAC by DEAL Supplements is straight up N-Acetyl Cysteine. Each serving contains 1000 mg of NAC—and 50 mg of reduced glutathione.
However, it contains several fillers in its formula that can have unpleasant side effects, making it #4 on our list.
Lastly, while DEAL Supplements offers a solid, 60-day money-back guarantee, you need to cover the cost of return shipping.
*Results are based on the Smarter Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn MoreDisclaimer:
Smarter Reviews is owned and operated by the same company that owns certain products featured on this website, including the products ranked number one.
In addition, we receive compensation from certain companies whose products are featured on this website when you purchase a product using the links on this website.
Go back to pageOur Main Sources
Sources used for research purposes. Smarter-Reviews.com are not officially affiliated with these sites.
What You Will Learn:
Estimated Read Time 5 Minutes
Benefits of a Quality NAC Supplement
CITATIONS
- https://www.ncbi.nlm.nih.gov/books/NBK279393/
- http://www.tocotrienolresearch.org/liver-health/
- https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/
- https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/